In 2010, ONT combined two technologies addressing each of the main outstanding problems. The first was an engineered nanopore developed in collaboration with Bayley’s lab that could discriminate between individual DNA bases, solving the resolution issue. The second was a trick to slow the DNA down to detectable speeds, using the familiar DNA polymerase enzyme. Mark Akeson’s lab at UC Santa Cruz had identified a specific polymerase from the bacterial virus ɸ29 that replicated DNA at an ideal speed for detection via nanopore. Template DNA strands were replicated just before entering the nanopore, passing through slowly enough for individual bases’ effect on the electrical current to be detectable and allowing the DNA sequence to be read one base at a time.
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。业内人士推荐快连下载安装作为进阶阅读
sys.stdout.write(u"\u001b[1000D")。WPS下载最新地址对此有专业解读
代码要点：倒序遍历，先算右侧再推左侧；栈内维护「右侧候选更大值」，单调递增（栈顶最小）。
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